Nano-Transfersomes of Vitamin-E and Aloe-Vera for The Management of Psoriasis

Psoriasis is a topical disease that leads to red and scratchy skin, most commonly on the knees, elbows, trunk scalp. an inflammatory constrains, aloe-vera, natural product, reported have anti-inflammatory properties. Further, Vitamin-E has antioxidant properties it can aid protect against some of oxidative burden occurs with psoriasis. Naturally, vitamin E broad spectrum benefits for health, hair. The aim present research was prepare characterized Nano-Transfersomes aloe-verafor management Nano-Transfersomespharmaceutical formulation prepared evaluated particle size, Zeta potential, drug entrapment, shape surface morphology, pH, viscosity, in vitrodrug release, skin irritation vitrostability. mean poly disparityindex (PDI), potential entrapment efficiency optimized Nano-transfersomal vesicles were 146.8±0.98 nm, 0.593, -38.5 Mv 92.29±4.51% respectively. revealed prolonged release during study 24h results more permeable through egg membrane from gel comparison marketed (Vitamin Gel Moisture Cream). aloe-vera containing found be highly efficacious as formulation, preparation indicated no any evidence irritancy mice. compatibility formulations which divulged therapeutic efficacy sustainable, biodegradable biocompatible manner